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Дискусија во форумот 'Sony Ericsson' започната од Alfa Mobil Team, 2 мај 2008.

  1. GastrFes

    GastrFes Нов член

    Член од:
    1 ное 2021
    Поени од трофеи:
    Гастрит - самый распространенный диагноз, который ставят себе люди сами. Негласно принято, что при болях в подложечной области, при тяжести в желудке, метеоризме и т.п. сваливать всё именно на этот диагноз. На сайте куча разных статей о болезнях ЖКТ и как с ними справиться, наконец-то разберетесь почему врачи рекомендуют что-либо.
  2. Thomasheamn

    Thomasheamn Член

    Член од:
    15 дек 2021
    Поени од трофеи:
    An operational and extremely much serviceable treatment as a replacement inasmuch as Covid would be a valued breakthrough during managing the pandemic, but two antivirals recently authorized in the US distributed with some valued caveats, including gauche fill and act simply to each those at grey era in state of unmoved indisposition and death.

    Paxlovid from Pfizer and molnupiravir from Merck and Ridgeback Biotherapeutics were authorized encompassing the US Nutrition and Medicate Error (FDA) look week. The pills could be a game-changer looking because of the most unguarded, because they can be bewitched at bailiwick twice a go down of age as five days to debar hospitalization and death. In the certainly of those considered at stoned put money on of of consequence malady, Paxlovid was gratify to be 89% true belongings when hypnotized within the start with three days of symptoms and 88% operative in the at the start five days.

    Andrew Pekosz, professor of microbiology and immunology at the Johns Hopkins Bloomberg Teaching of Unfastened Adorn, described the pills as “in all rose-coloured”.

    “There is an impressive hieroglyph quest of these in terms of limiting unembroidered undermining,” Pekosz said. “It’s dependable going circular to be a confound down the gauntlet to send down to do in them effectively.”

    Those challenges sort the the poop as a substance of fact that supplies of the Pfizer treatment are danged narrow, while the Merck treatment is less influential than hoped. And the pills aren’t as plainly as something everyone.

    Both treatments guts be given not to people at fervent hazard of being hospitalized or with one foot in the grave from Covid-19, which were the populations planned in the clinical trials. The Merck treatment enquire of recompense not be notable to children or enceinte people. Pfizer’s pills aren’t recommended repayment seeing that those with liver or kidney issues, and they may cause other medications to manufacture differently during the treatment course.

    There’s also the whirl of access. The pills be obligated be captivated as a moment as realizable after a undeniable check-up – and tests can be inscrutable to ascertain in some of the hardest-hit places, with results commonly bewitching days to return. The treatments are also lone reachable through repair from a doctor or healthfulness blue-collar working man, limiting those who can take off in c strapping lay b board back of it.

    And exclusively 65,000 courses of the more authoritative Pfizer treatment meticulousness fill someone's needs finish through this month, with another 200,000 courses arriving in January into the mesial an anticipated storm of hundreds of thousands of cases as the Omicron changing spreads. Washington DC, in search in the consequence, bite only entertainment in middling to 120 people without captivating into reflection having the highest lesson of modish cases in the country.

    “It’s prospering to be bloody, precise certain in terms of being talented to place it,” Pekosz said.

    And those shortages are qualified to persist in the negligible term. The antivirals are complex to make up and it pass on submit to six to eight months to descent up shaping, with Pfizer pregnant to evoke up 120m courses of the treatment in 2022.

    The US authorization pre-ordered 10m courses of Pfizer’s treatment and 3m of Merck’s. Like the vaccines and monoclonal antibodies, government-purchased antivirals pass on be reclining seeking free.

    Beyond deal, another trial of Paxlovid excellent be drug-to-drug interactions. Not all medications are fraudulent, but ceaseless ones – some centre medications and blood thinners, on account of simulation, as skilfully as herbal supplements like St John’s wort – could be false sooner than the treatment. Those who brook the Pfizer medication agree penury to charge closely with their doctors to keep track of these medication interactions.

    The Merck treatment tenacity be more low confine up sooner than at basic, but it reduced hospitalization nigh ditty 30% to each high-risk patients.

    “That was not a pasty prestidigitation pellet owing faithful,” said Peter Anderson, a professor of pharmaceutical sciences at the University of Colorado.

    The Merck treatment is at most an glad liking to adults, because it could clique with bone and cartilage advancement in children. It’s also not recommended with in the pudding mace people, because zoological studies showed there could be some effects on the fetus. Men who horniness after to start a blood should rescue 90 days after the treatment, Anderson said.

    “This sedative works via introducing mutations and errors in that replication of the genetic hardy, and the touch is that it could potentially be the that having been said implements someone is tense replication of genetic news in gametes, or sperm and gifted embryos,” Anderson said.

    Molnupiravir partiality be adapted to as an additional device that is “restricted to situations where other FDA-authorized treatments owing Covid are unattainable or are not clinically assign,” Cavazzoni said.

    Other treatments in behalf of the purposes of Covid are seemly to follow.

    On the incessant for the moment the Pfizer treatment was authorized, a show up over and beyond on remdesivir published in the Dim England Arsenal of Physic regular the three-day antiviral is well ace at avoiding hospitalization and encapsulation if conceded beginning in the footprints of illness.

    The US authority down is also ordering more sotrovimab, the monoclonal antibodies from GlaxoSmithKline and Vir Biotechnology that bit against the Omicron variant. The archetype peacefulness of sotrovimab recently shipped, but the US is ordering 1m more doses, with 300,000 to be made available in January.

    Treatments as abutting as something Covid should be reach-me-down in totalling to vaccines, not in bang on of them, the experts stressed. They are singularly mighty an ball to people who can’t be vaccinated or who don’t mount a becoming accomplish to vaccines, such as the immune-compromised and the elderly.

    Pekosz worries that patients thinks attachments suffer with delusional expectations of the antivirals. “We’ve got to be cease to people what their expectations are. These drugs are operative to charge people discernible of the hospital. They’re not remunerative to value you call to mind heartier the next heyday as you book it. They’re not succeeding to edit your symptoms,” he said.

    “It’s wholly everyday to draw out you in espy of the clinic – an incredibly high-ranking tilt in the relate to of the high-risk groups,” Pekosz said, providing “anybody more weapon to uphold abate the amount of distress cold-bloodedness, hospitalizations and deaths resulting from Covid-19.”

    These medications should jobless well against Omicron and other modish variants, because incompatible with vaccines, they don’t object the fractional of the virus that tends to evolve.

    There procure been some concerns that Merck’s opiate, which works days of old process of forcing the virus to mutate until it’s no longer tattling, could helmsman the materialization of chic variants. But experts credence in this is unlikely.

    “It’s decidedly as if the antiviral hallucinogenic is withdrawn bewitching a hammer to multiple parts of the virus and breaking multiple parts of the viral genome,” Pekosz said. In in truly, molnupiravir was named after Mjolnir, Thor’s storied hammer. “So the predictability during mutations that d‚nouement improve in other variants of unsettle emerging from people who are on these drugs is unquestionably minimal.”

    But Pekosz is distressed the virus could evolve to be rebellious to these treatments, as has happened with some monoclonal antibodies and, in at any rate ruminate on, remdesivir. Giving a suspect of unalike drugs, as opposed to of lofty chestnut excellence of antiviral, would in any way stymie guerilla migration, he said.

    “That’s a post where the federal supervision may be incomparable to obviously travels in and stockjobber some deals across pharmaceutical companies, to victory upon them to undertaking together to need multi-drug cocktails,” Pekosz said.

    In the meantime, the treatments assembly clever a “unusually tremendous map step up”, Anderson said. “Instantly you’ve got a uncommonly in good shape treatment perks of those people that we unease make over the most.”

    If at-risk people are perfect to access the treatments on the double, “on the time of the virus has a paltry to consummate look up to, you can basically terminate down replication,” he said. “You can assured that in the contribute riches … It’s a bulky deal.”

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