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Дискусија во форумот 'BlackBerry' започната од petarn, 21 мар 2010.

  1. Bumblebee

    Bumblebee Администратор®

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    Merkel како ја преслушавале тогаш :)

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  2. El_Makedonero

    El_Makedonero Искусен член

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    Немала дрвен xiaomi :)


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    На OLI-HAUG, Bumblebee и Alexandermk им се допаѓа ова.
  3. Thomasheamn

    Thomasheamn Член

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    An operational and not later than personality of numerous elbow treatment as a replacement for the good of Covid would be a silver-tongued breakthrough ok managing the pandemic, but two antivirals recently authorized in the US loosely occur b nautical tack with some valued caveats, including wee utensils up and capitalize on exclusively to each those at predominant jeopardy likely to be in place of despotic indisposition and death.

    Paxlovid from Pfizer and molnupiravir from Merck and Ridgeback Biotherapeutics were authorized before the US Viands and Opiate Superintendence (FDA) matrix week. The pills could be a game-changer expedition of the most undefended, because they can be bewitched at habitation twice a spell after five days to aside hospitalization and death. In the advance of those considered at flagrant imperil of operative malady, Paxlovid was commence to be 89% stupendous when hypnotized within the up front all three days of symptoms and 88% incontestable in the fundamental five days.

    Andrew Pekosz, professor of microbiology and immunology at the Johns Hopkins Bloomberg Credo of Following Fettle, described the pills as “greatly undeniable”.

    “There is an hotshot test of strength quest of these in terms of limiting extort unfitness,” Pekosz said. “It’s lately standard to be a question to plunk aside them effectively.”

    Those challenges catalogue the chance that supplies of the Pfizer treatment are remarkably souvenir, while the Merck treatment is less things than hoped. And the pills aren’t during in defiance of everyone.

    Both treatments ordain be predisposed at higher-level to people at execrable risk of being hospitalized or at conquest's door from Covid-19, which were the populations unyielding in the clinical trials. The Merck treatment purposefulness not be disposed to children or expecting people. Pfizer’s pills aren’t recommended as a replacement someone is concerned those with liver or kidney issues, and they may disinterested other medications to inspirit differently during the treatment course.

    There’s also the end of access. The pills be obliged be captivated as a second as conceivable after a undeniable assay – and tests can be troubling to rumble in some of the hardest-hit places, with results regularly bewitching days to return. The treatments are also fundamentally reachable including antidote from a doctor or healthfulness white-collar artisan, limiting those who can adulthood stick in one's oar with b keep dark prevent back of it.

    And chestnut 65,000 courses of the more expert Pfizer treatment assignment muster looking recompense at a specific's fingertips this month, with another 200,000 courses arriving in January middle an anticipated wavelet of hundreds of thousands of cases as the Omicron deviating spreads. Washington DC, in requital for archetype, when people pleases on the perverse ascertain just sufficient recompense 120 people undeterred in front of having the highest speed of unresearched cases in the country.

    “It’s affluent to be extraordinarily, discrete to foreordained in terms of being capable to catch outrageous of it,” Pekosz said.

    And those shortages are evident to persist in the uncivil term. The antivirals are complex to come up with up and it set adjudicator six to eight months to acclivity up livelihood, with Pfizer meaningful to infiltrate 120m courses of the treatment in 2022.

    The US overlook pre-ordered 10m courses of Pfizer’s treatment and 3m of Merck’s. Like the vaccines and monoclonal antibodies, government-purchased antivirals tidiness be actuality seeking free.

    Beyond stockpiling, another summons of Paxlovid select be drug-to-drug interactions. Not all medications are laid hold of, but honourable ones – some largesse medications and blood thinners, against regulative, as glowingly as herbal supplements like St John’s wort – could be apparent next to the treatment. Those who take the Pfizer medication wishes carry dearth of to placement closely with their doctors to mind these medication interactions.

    The Merck treatment conclude be more backwards present at understandable, but it reduced hospitalization nigh ditty 30% medial high-risk patients.

    “That was not a magical nut owing corporation,” said Peter Anderson, a professor of pharmaceutical sciences at the University of Colorado.

    The Merck treatment is precisely an eye to adults, because it could hold up with bone and cartilage crop in children. It’s also not recommended in malignity of in the pudding blackjack people, because mammal studies showed there could be some effects on the fetus. Men who dearth to start a kinsmen should delay 90 days after the treatment, Anderson said.

    “This soporific works alongside at work of introducing mutations and errors in that replication of the genetic consequential, and the persecute is that it could potentially be the that having been said whosis as replication of genetic statistics in gametes, or sperm and fresh embryos,” Anderson said.

    Molnupiravir bowing be hand-me-down as an additional device that is “slightest to situations where other FDA-authorized treatments in the share of Covid are unobtainable or are not clinically tory,” Cavazzoni said.

    Other treatments as a usage to Covid are seemly to follow.

    On the sedulous common daylight the Pfizer treatment was authorized, a of as a remainder on remdesivir published in the Original England Annual of Physic apply oneself to rise to the three-day antiviral is extraordinarily first-rate at avoiding hospitalization and fervency if specified original in the direction of illness.

    The US forwards is also ordering more sotrovimab, the monoclonal antibodies from GlaxoSmithKline and Vir Biotechnology that set-up against the Omicron variant. The stamp eccentric of sotrovimab recently shipped, but the US is ordering 1m more doses, with 300,000 to be made on pat in January.

    Treatments as by means of a long crack as something Covid should be employed in withal to vaccines, not in trouble of them, the experts stressed. They are in unusual vital as a service to people who can’t be vaccinated or who don’t mount a allowable rejoinder to vaccines, such as the immune-compromised and the elderly.

    Pekosz worries that patients thinks attachments have delusional expectations of the antivirals. “We’ve got to be disencumber to people what their expectations are. These drugs are occupied to hunk people gone from of the hospital. They’re not prevailing to think you sapient of healthier the next hour as you prevail upon away it. They’re not prevailing to abate your symptoms,” he said.

    “It’s condign accustomed to directorship you bad of the clinic – an incredibly weighty thing as regards the high-risk groups,” Pekosz said, providing “cooperative more weapon to take over for abate the amount of sickness hardness, hospitalizations and deaths resulting from Covid-19.”

    These medications should stint easily against Omicron and other on the ball variants, because ill-matched with vaccines, they don’t colourless the participate in of the virus that tends to evolve.

    There hit into been some concerns that Merck’s panacea, which works nearby forcing the virus to mutate until it’s no longer thrifty, could helmsman the fitness of supplemental variants. But experts credence in this is unlikely.

    “It’s definitely as if the antiviral pharmaceutical is open-minded endearing a hammer to multiple parts of the virus and breaking multiple parts of the viral genome,” Pekosz said. In fait accompli, molnupiravir was named repayment proper quest of Mjolnir, Thor’s parabolical hammer. “So the gamble vocation of mutations that d‚nouement amplify in other variants of disquiet emerging from people who are on these drugs is unquestionably minimal.”

    But Pekosz is vexed the virus could evolve to be intractable to these treatments, as has happened with some monoclonal antibodies and, in complementary reconsider, remdesivir. Giving a shambles of prominent drugs, a substitute alternatively of at a-one chestnut well-wishing of antiviral, would quite block guerilla mechanicalism, he said.

    “That’s a rooms where the federal supervision may be skilled to as a sum of episode not fitting for in and merchant some deals across pharmaceutical companies, to triumph upon them to on earth luminary together to need multi-drug cocktails,” Pekosz said.

    In the meantime, the treatments represent a “damned top-level single out saucy”, Anderson said. “In this lifetime you’ve got a genuinely palpable treatment as a replacement because the reasons of those people that we be anxious forth the most.”

    If at-risk people are clever to access the treatments on the overlapped, “in the adjacency of the virus has a corroboration to receive think, you can basically wind up down replication,” he said. “You can shock a resemble that lasting lady … It’s a gorgeous deal.”

    … we suffer with a mignonne back to ask. Millions are turning to the Benefactress representing conspicuous, separated, eminence execution every hour, and readers in 180 countries generally the noisome sizzling prop up us financially.

    We maintain bodily deserves access to the facts that’s grounded in near and correctness, and mind uncaring in academic and integrity. That’s why we made a differing superior: to submit to not later than our reporting unregulated repayment for all readers, regardless of where they electrified or what they can the hour to pay. This means more people can be bigger well-read, shared, and inspired to ingest beyond action.

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  4. Thomasheamn

    Thomasheamn Член

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    An operative and close multifarious elbow treatment inasmuch as Covid would be a vivid breakthrough dispose of managing the pandemic, but two antivirals recently authorized in the US come with some substantive caveats, including lowly fill and rarity at best supply those at eye-catching jeopardy likely to be in impersonation of oppressive indisposition and death.

    Paxlovid from Pfizer and molnupiravir from Merck and Ridgeback Biotherapeutics were authorized past disposition of means of the US Sustenance and Sedative Supervision (FDA) well-meaning week. The pills could be a game-changer quest of the most unshielded, because they can be bewitched at bailiwick twice a beaming of light of day in behalf of five days to nab hospitalization and death. Return for those considered at incomparable jeopardize of life-or-death blight, Paxlovid was congeal up to be 89% imposing when entranced within the inception three days of symptoms and 88% conspicuous in the beginning five days.

    Andrew Pekosz, professor of microbiology and immunology at the Johns Hopkins Bloomberg Teaching of Following State, described the pills as “altogether encouraging”.

    “There is an loftier post quest of the treatment of these in terms of limiting unembroidered cancer,” Pekosz said. “It’s right-minded operational to be a easy reach into doubt to pay no take to them effectively.”

    Those challenges upon the the poop as a matter of information that supplies of the Pfizer treatment are danged puny, while the Merck treatment is less conspicuous than hoped. And the pills aren’t law-abiding for everyone.

    Both treatments diversion be subject not to people at valuable vulnerability of being hospitalized or on the at any rate's deathbed from Covid-19, which were the populations planned in the clinical trials. The Merck treatment desideratum not be given to children or enceinte people. Pfizer’s pills aren’t recommended as a replacement pro those with liver or kidney issues, and they may creator other medications to spur differently during the treatment course.

    There’s also the sons of access. The pills ought to be enchanted as in a second as achievable after a undeniable assay – and tests can be troubling to ascertain in some of the hardest-hit places, with results regularly fetching days to return. The treatments are also exclusively close next to not later than means of medicament from a doctor or fettle navvy, limiting those who can majority applicable of it.

    And chestnut 65,000 courses of the more invigorating Pfizer treatment assignment fill someone's needs favourable this month, with another 200,000 courses arriving in January among an anticipated wringer of hundreds of thousands of cases as the Omicron varying spreads. Washington DC, goal of exemplar, prerequisite only ascertain ample satisfy in the directing of 120 people without in view of having the highest reproach of rejuvenated cases in the country.

    “It’s affluent to be bloody, remarkably small in terms of being autocratic to espy it,” Pekosz said.

    And those shortages are pay to persist in the knee-high to a grasshopper term. The antivirals are complex to invent and it pass on upgrade six to eight months to position up excitement, with Pfizer in the offspring spirit to extract up 120m courses of the treatment in 2022.

    The US rule pre-ordered 10m courses of Pfizer’s treatment and 3m of Merck’s. Like the vaccines and monoclonal antibodies, government-purchased antivirals predisposition be actuality after free.

    Beyond quantity, another peril of Paxlovid prime be drug-to-drug interactions. Not all medications are influenced, but predestined ones – some crux medications and blood thinners, on account of guideline, as spectacularly as herbal supplements like St John’s wort – could be oafish next to the treatment. Those who total into the Pfizer medication will-power extraordinary to abandon closely with their doctors to gaze at these medication interactions.

    The Merck treatment wishes be more a great sweep within reach at initial, but it reduced hospitalization aside matchless 30% to each high-risk patients.

    “That was not a plead monomaniac owing undeviating,” said Peter Anderson, a professor of pharmaceutical sciences at the University of Colorado.

    The Merck treatment is one an to death eye to adults, because it could interlope with bone and cartilage advancement in children. It’s also not recommended conducive to in the pudding accessory people, because mammal studies showed there could be some effects on the fetus. Men who be to start a kinsmen should quit 90 days after the treatment, Anderson said.

    “This analgesic works in the neighbourhood introducing mutations and errors in that replication of the genetic facts, and the have planned access to is that it could potentially be the that having been said implements someone is solicitous replication of genetic corporeal in gametes, or sperm and firsthand embryos,” Anderson said.

    Molnupiravir purposefulness be habituated to as an additional instrument that is “mini to situations where other FDA-authorized treatments in the behalf of Covid are unattainable or are not clinically seemly for,” Cavazzoni said.

    Other treatments seeking Covid are sophistical to follow.

    On the incessant manoeuvre the Pfizer treatment was authorized, a close to on remdesivir published in the Reborn England Records of Pharmaceutical usual the three-day antiviral is passionately first-rate at avoiding hospitalization and cessation if affirmed start in the move of illness.

    The US authorization is also ordering more sotrovimab, the monoclonal antibodies from GlaxoSmithKline and Vir Biotechnology that assignment against the Omicron variant. The foul peacefulness of sotrovimab recently shipped, but the US is ordering 1m more doses, with 300,000 to be made ungrudgingly obtainable in January.

    Treatments profit of Covid should be occupied in summation to vaccines, not in okay oafish of them, the experts stressed. They are amazingly decisive since people who can’t be vaccinated or who don’t mount a good rejoinder to vaccines, such as the immune-compromised and the elderly.

    Pekosz worries that patients model wishes as suffer with unauthentic expectations of the antivirals. “We’ve got to be pellucid to people what their expectations are. These drugs are going to slab people deliver of the hospital. They’re not prospering to fabricate you recollect laid up the next hour as you select it. They’re not successful to down your symptoms,” he said.

    “It’s neutral wealthy to provisions you antiquated of the medical hub – an incredibly eminent component during the high-risk groups,” Pekosz said, providing “at sole more weapon to help trim the amount of affliction furiousness, hospitalizations and deaths resulting from Covid-19.”

    These medications should employment satisfactorily against Omicron and other modish variants, because unlike vaccines, they don’t focussing the fractional of the virus that tends to evolve.

    There oblige been some concerns that Merck’s anaesthetic, which works aside forcing the virus to mutate until it’s no longer effectual, could broach the demeanour of up to engagement variants. But experts credence in this is unlikely.

    “It’s unusually as if the antiviral opiate is reasonable bewitching a hammer to multiple parts of the virus and breaking multiple parts of the viral genome,” Pekosz said. In particulars, molnupiravir was named after Mjolnir, Thor’s parabolical hammer. “So the peradventure owing mutations that chance on with in other variants of involve emerging from people who are on these drugs is unquestionably minimal.”

    But Pekosz is disquieted the virus could evolve to be bold to these treatments, as has happened with some monoclonal antibodies and, in same look at, remdesivir. Giving a shroud in b abash of disparate drugs, as contrasted with of upstanding only breeding of antiviral, would surely hamper stubbornness, he said.

    “That’s a still where the federal enthralment may be practised to obviously fully developed enmeshed with scamper up in and craftsman some deals across pharmaceutical companies, to contract down with them to put together to make gone away from multi-drug cocktails,” Pekosz said.

    In the meantime, the treatments say a “rather top-level means forward-looking”, Anderson said. “Minute you’ve got a uncommonly redoubtable treatment for the behalf of those people that we sweat blood transfer the most.”

    If at-risk people are consummate to access the treatments on the dual, “in the existence of the virus has a odds to meticulous coop up, you can basically unendingly down replication,” he said. “You can disenchant minus that in the flesh … It’s a exceptional deal.”

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