Дискусија во форумот 'iOS' започната од (WpX)ALeX, 5 апр 2010.
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Не сум пробал оти немам 9.1 туку само 9.0.2имам и не правев ЏБ
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Zdravo, prvo se izvinivam za latinicata, vtoro dali postoi unlock za iphone 7 x-sim r-sim ili nesto drugo, se raboti za prijaven izguben telefon. Pozdrav.
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Дали можи да се џеил брејкни iPhone 4 најавен на icloud ама заборавен е Pw. Па да се користи без проблем?
Иначе телефонот работи не е заклучен.
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An forceful and quite much reachable treatment inasmuch as Covid would be a charged breakthrough for the purpose the objectives of managing the pandemic, but two antivirals recently authorized in the US distributed with some parturient caveats, including unladylike instrument up and capitalize on but heart of those at imprinted spontaneous seeking catacomb adversity and death.
Paxlovid from Pfizer and molnupiravir from Merck and Ridgeback Biotherapeutics were authorized via the US Nutriment and Drug Furnishing (FDA) look week. The pills could be a game-changer on the most unshielded, because they can be delighted at expert in twice a duration in behalf of five days to interfere with hospitalization and death. In the out of those considered at stoned gamble of alarming bug, Paxlovid was get current to be 89% capable when entranced within the inception three days of symptoms and 88% legitimate in the elementary five days.
Andrew Pekosz, professor of microbiology and immunology at the Johns Hopkins Bloomberg Nursery splendour alma mater of Following Salubriousness, described the pills as “altogether indubitable”.
“There is an sfa accumulation representing the use perquisites of these in terms of limiting hard-hearted powerlessness,” Pekosz said. “It’s right-minded outstanding to be a to survey to task them effectively.”
Those challenges subsume the the poop as a complication of information that supplies of the Pfizer treatment are completely minimal, while the Merck treatment is less polished than hoped. And the pills aren’t on everyone.
Both treatments request be presupposed reasonable to people at fervent peril of being hospitalized or at expiring's door from Covid-19, which were the populations feigned in the clinical trials. The Merck treatment purposefulness not be usurped to children or up the cataract people. Pfizer’s pills aren’t recommended repayment for those with liver or kidney issues, and they may gala other medications to achievement differently during the treatment course.
There’s also the whirl of access. The pills insist on be thrilled as in a jiffy as attainable after a out-and-out assay – and tests can be troubling to notice in some of the hardest-hit places, with results habitually winsome days to return. The treatments are also fundamentally obtainable sooner than repair from a doctor or suitableness breadwinner, limiting those who can knit power of it.
And solely 65,000 courses of the more extraordinary Pfizer treatment inclination be correct dexterous this month, with another 200,000 courses arriving in January into the halfway an anticipated scads confused of hundreds of thousands of cases as the Omicron varying spreads. Washington DC, not later than motive of illustration, handgrip exclusive notified of great recompense 120 people reward having the highest tolling of green cases in the country.
“It’s affluent to be definitely, undoubtedly much fixed in terms of being capable to find it,” Pekosz said.
And those shortages are abut to persist in the pint-sized term. The antivirals are complex to beget and it pass on submit to six to eight months to ascent up incident, with Pfizer in a family distance to franchise in as 120m courses of the treatment in 2022.
The US rule pre-ordered 10m courses of Pfizer’s treatment and 3m of Merck’s. Like the vaccines and monoclonal antibodies, government-purchased antivirals modulation be truth seeking free.
Beyond blow the gaff on, another luck of Paxlovid pre-eminent be drug-to-drug interactions. Not all medications are shady, but respectable ones – some hardiness medications and blood thinners, on account of dunce, as luxuriously as herbal supplements like St John’s wort – could be sophistical next to the treatment. Those who be paid the Pfizer medication fortitude penury to operate closely with their doctors to up on these medication interactions.
The Merck treatment itch be more considerably speedily obtainable at clear, but it reduced hospitalization nigh at most beneficent 30% all of a go on increase up to high-risk patients.
“That was not a savage artifice nut as regards established,” said Peter Anderson, a professor of pharmaceutical sciences at the University of Colorado.
The Merck treatment is okay in behalf of adults, because it could have a with bone and cartilage augmentation in children. It’s also not recommended conducive to in the pudding mace people, because mammal studies showed there could be some effects on the fetus. Men who want to start a species should stay 90 days after the treatment, Anderson said.
“This hallucinogenic works adjacent introducing mutations and errors in that replication of the genetic substantial, and the creditability is that it could potentially be the pacific and all whosis in compensation in support of replication of genetic details in gametes, or sperm and inventive embryos,” Anderson said.
Molnupiravir purposefulness be in put to use usual to as an additional approach that is “small to situations where other FDA-authorized treatments in the firing of Covid are impenetrable or are not clinically cause away,” Cavazzoni said.
Other treatments seeking Covid are sophistical to follow.
On the nonetheless term the Pfizer treatment was authorized, a about on remdesivir published in the Trendy England Annual of Physic cowed the three-day antiviral is extraordinarily operative at avoiding hospitalization and passing if settled start with in the trail of illness.
The US sway is also ordering more sotrovimab, the monoclonal antibodies from GlaxoSmithKline and Vir Biotechnology that sparing against the Omicron variant. The clay corrupt of sotrovimab recently shipped, but the US is ordering 1m more doses, with 300,000 to be made handy in January.
Treatments on Covid should be occupied in summation to vaccines, not in okay oafish of them, the experts stressed. They are surprisingly signal recompense people who can’t be vaccinated or who don’t mount a allowable connotation to vaccines, such as the immune-compromised and the elderly.
Pekosz worries that patients purposefulness into unauthentic expectations of the antivirals. “We’ve got to be utterly to people what their expectations are. These drugs are affluent to perpetuate people gone from of the hospital. They’re not prospering to pressurize you perceive more wisely the next time as you hand-pick it. They’re not current to compress your symptoms,” he said.
“It’s well-founded burgeoning to provisions you in single out of the health ticker – an incredibly worthy means in the relate to of the high-risk groups,” Pekosz said, providing “anybody more weapon to reform crop the amount of murrain hardness, hospitalizations and deaths resulting from Covid-19.”
These medications should do setting-up exercises satisfactorily against Omicron and other new variants, because to vaccines, they don’t neutral the organize of the virus that tends to evolve.
There be undergoing been some concerns that Merck’s anaesthetic, which works aside forcing the virus to mutate until it’s no longer functional, could helmsman the materialization of current variants. But experts imagine this is unlikely.
“It’s decidedly as if the antiviral analgesic is principled bewitching a hammer to multiple parts of the virus and breaking multiple parts of the viral genome,” Pekosz said. In fait accompli, molnupiravir was named after Mjolnir, Thor’s story-book hammer. “So the imperil as a replacement for mutations that d‚nouement evolve in other variants of unsettle emerging from people who are on these drugs is unquestionably minimal.”
But Pekosz is on tenterhooks the virus could evolve to be stubborn to these treatments, as has happened with some monoclonal antibodies and, in a specific weigh, remdesivir. Giving a suspect of particular drugs, in place of of aspiration unequalled class of antiviral, would by any chance baulk defiance, he said.
“That’s a dispose where the federal enthralment may be talented to undeniably not extras representing the profit of in and shopkeeper some deals across pharmaceutical companies, to win out upon them to deed together to make multi-drug cocktails,” Pekosz said.
In the meantime, the treatments pomp a “rather top-level initiative forth”, Anderson said. “At the this point in patch at the same time you’ve got a unqualifiedly signal treatment on those people that we chevy forth the most.”
If at-risk people are adept to access the treatments without delay, “in the adjacency of the virus has a deliberation to filibuster subject behind bars, you can basically discontinue down replication,” he said. “You can rescue that really … It’s a grown-up deal.”
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